The Muscat sisters, Christine (born 27 February 1981) and Sharon (born 23 August 1984) (to Maltese immigrants), are the duo that make up Sister2Sister. Their career started young when they grew up in the Sydney suburb of St. Clair, where they attended Holy Spirit Primary school and later Emmaus Catholic College in nearby Erskine Park.

Growing up in a musical family, it was during those early years that the two developed a love for music. However, they also had a knack for acting, which resulted in both of them television presenting and landing roles in TV commercials and soap operas.