Following Izzy Stradlin departure from Guns N' Roses, Stradlin returned to his hometown of Lafayette, Indiana, where he began working on new material. He formed the band Izzy Stradlin and the Ju Ju Hounds, which consisted of Stradlin on vocals and rhythm guitar, Rick Richards of Georgia Satellites on lead guitar, Jimmy Ashhurst of Broken Homes on bass, and Charlie Quintana on drums. Their self-titled debut album was released in October 1992 to critical acclaim; Rolling Stone called it "a ragged, blues-drenched, and thoroughly winning solo debut." Ju Ju Hounds played its first show in September at The Avalon in Chicago, before embarking on a tour of Europe, Australia, and North America.

In May 1993, Stradlin reunited with Guns N' Roses for five shows in Europe and the Middle East to fill in for his replacement, Gilby Clarke, who had broken his wrist in a motorcycle accident.After Stradlin returned to the Ju Ju Hounds, Axl Rose dedicated the Stradlin-penned "Double Talkin' Jive" to him during several shows.In September, the Ju Ju Hounds undertook a tour of Japan, where the band played its final show at the Shibuya Public Hall in Tokyo.Stradlin then took time off from music, during which he traveled extensively and dedicated much of his time to his other passion–motor racing, even building a track close to his Indiana home.