Regina Resnik (born August 30, 1922) is an American operatic singer.

Regina Resnik, the American mezzo-soprano, started a dramatic career ten months after earning her B.A. in Music at Hunter College. The role was Lady Macbeth under Fritz Busch in December, 1942 with the New Opera Company. A few months later, she sang Fidelio and Micaela under Erich Kleiber in Mexico City. In between she sang Santuzza with the fledgling New York City Opera and, performing "Ernani, Involami", won the Metropolitan Opera Auditions of the Air and her contract with that company for the 1944-45 season.