Otis Spann (March 21, 1930 – April 24, 1970 ) was an American blues musician. Many aficionados considered him then, and now, as Chicago's leading postwar blues pianist.

Born in Jackson, Mississippi, Otis Spann became known for his distinct piano style.

Born to Frank Houston Spann and Josephine Erby. One of five children - three boys and two girls. His father played piano, non professionally, while his mother had played guitar with Memphis Minnie. Spann began playing piano by age of eight, influenced by his local ivories stalwart, Friday Ford. At the age of 14, he was playing in bands around Jackson, finding more inspiration in the 78s of Big Maceo Merriweather, who took the young pianist under his wing once Spann migrated to Chicago in 1946. Other sources say that he moved to Chicago when his mother died in 1947 playing the Chicago club circuit and working as a plasterer. Spann gigged on his own, and with guitarist Morris Pejoe, working a regular spot at the Tic Toc Lounge before hooking up with Muddy Waters in 1952.